X-PEL
Mebendazole is an anthelmintic or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.
Presentation
30 ml suspension in amber coloured glass bottle
Description
Indications
X-Pel suspension is indicated for the treatment of single or mixed helminthic infestations, treatment of Enterobius vermicularis (threadworm), Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and of Ancylostoma duodenale and Necator americanus (hookworm).
Pharmacological class
Anthelmintic
Pharmacological properties
Anthelmintic
Mechanism of Action
The mechanism of action is probably a result of an inhibitory effect on the ability of the organism to utilise exogenous glucose. This interferes with the generation of phosphate bonds (ATP), ultimately leading to the death of the parasite.
Side effects
Patients with high parasitic burdens when treated with X-Pel have manifested diarrhoea, vomiting, and/or abdominal pain. Others are drowsiness, itching, headache, and dizziness. Reports from clinical trials also mentioned increased AST, ALT, alkaline phosphatase, and BUN. Eosinophilia and decreased haemoglobin and/or white cell count, haematuria and cylindrunia have been reported.
Contraindications
Mebendazole is contraindicated in persons who have shown hypersensitivity to the drug or other benzimidazole derivatives.
Drug interactions
Concurrent treatment with cimetidine may inhibit the metabolism of mebendazole in the liver, resulting in increased plasma concentrations, particularly during prolonged treatment.
Other drugs may interact with mebendazole, including prescription and over-the-counter medicines, vitamins, and herbal products
