DOXYREN
Doxyren (Doxycycline) belongs to a group of Tetracyclines and is obtained from demeclocycline, It is active against wide range of gram-negative and gram-positive bacteria. Also active against Rickettsia, Mycoplasma, Chlamydia, mycobacteria.
Presentation
Blister pack of 10×10 Doxyren capsules
Description
Indications:
Doxycycline is indicated in the treatment of infections due to rickettsia, mycoplasma and chlamydia. Also in non-specific urethritis, chancroid, granuloma inguinale, melioidosis, sexually transmitted diseases, though penicillins are preferred, it is recommended for people sensitive to penicillins.
Pharmacological class
Antibacterial
Pharmacological properties
Bactericidal
Mechanism of action
Doxycycline interferes with protein synthesis by binding to ribosomes and preventing access of transfer RNA-amino acid complexes to messenger RNA-ribosome complexes. This prevents addition of amino acid to the growing peptides.
Side-effects
These include epigastric distress, nausea and vomiting, photosensitivity and hepatotoxicity.
Doxycycline also causes discolouration of teeth, this is severe in neonates and babies prior to the first dentations hence not advisable for this age group.
Contraindications:
Doxycycline is contraindicated in patients having known hypersensitivity to it.
Drug Interactions:
Tetracyclines chelate calcium and iron in the stomach, and their absorption is reduced by the presence of antacids or food.
