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RECIM

Cimetidine is a H2 (histamine-2) that blocks the production of acid by acid-producing cells in the stomach and can be administered orally, IM or IV. Cimetidine is prescribed for the treatment of GERD, duodenal ulcers, active gastric ulcers, Zollinger Ellison syndrome, heartburn, indigestion; and the prevention of gastrointestinal bleeding.

Presentation
Blister pack of 10 x 10 Tablets

Description

Indications
Treatment and maintenance therapy of active duodenal ulcer, benign gastric ulcers, reflux oesophagitis, pathological hypersecretory conditions (Zollinger – Ellison Sydrome)
Pharmacological class
Antiacid
Pharmacological properties
Reduced acid secretion
Mechanism of action
Cimetidine competitively inhibits the action of histamine at the H2 receptor antagonist that blocks the production of acid by acid-producing cells in the stomach
Side effects
Confusion and hallucinations (usually in elderly or critically ill patients), enlargement of the breasts; impotence (usually seen in patients on high doses for prolonged periods); decreased white blood cell counts, allergic reactions, rash, visual changes
Contraindications
Cimetidine is contraindicated in patients with the history of hypersensitivity to it.
Drug interactions
Cimetidine increases the metabolism of the following drugs;
Warfarin-Type anticoagulants, Phenytoin, nifedipine, chlordiazepoxide, diazepam, lidocaine, theophylline, metronidazole. Cimetidine inhibits the absorption of ketoconazole by altering its PH.

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